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April 17, 2020Coronavirus, Exercise, Health & Medical

Regular Exercise Can Protect 

Against Deadly Coronavirus 

Complications, Study Says

by Chris Melore

Dr. Zhen Yan: “We cannot live in isolation forever. 

Regular exercise has far more health benefits than we know. 

The protection against this severe 

respiratory disease condition 

is just one of the many examples.”


CHARLOTTESVILLE, Va. — 

Acute respiratory distress syndrome (ARDS) is one of 

the major complications caused by COVID-19. 

Even though only a small percentage of coronavirus 

patients develop ARDS, the majority of those cases 

end up in the intensive care unit. According to a 

researcher at the University of Virginia School of 

Medicine, regular exercise could hold the key to 

keeping patients from developing deadly

 complications like ARDS.

.

Dr. Zhen Yan says his research found a 

powerful antioxidant that helps protect 

against disease and can be

 produced through exercise. 

Yan’s study shows ARDS affects 

between three and 17 percent of COVID-19 patients. 

The Centers for Disease Control and Prevention 

adds that about 20 to 42 percent of hospitalized 

coronavirus cases will develop ARDS. 

Prior to the global pandemic, researchers said 

nearly half of severe ARDS cases turn fatal.

Zhen Yan, PhD
Zhen Yan, PhD, is top exercise researcher. He is the director of the Center for Skeletal Muscle Research at UVA’s Robert M. Berne Cardiovascular Research Center. (Photo Credit: Dan Addison | UVA Communications)

“All you hear now is either social distancing or ventilator, 

as if all we can do is either avoiding exposure 

or relying on a ventilator to survive if we get infected,” 

Yan said in a statement. “The flip side of the story is

 that approximately 80% of confirmed COVID-19 

patients have mild symptoms 

with no need of respiratory support.”

Yan explains that the antioxidant 

extracellular superoxide dismutase (EcSOD) 

could have a lot to do with keeping 

the majority of coronavirus cases mild.

The study says EcSOD hunts down free

 radicals and protects the body’s tissue 

from disease. Our muscles naturally 

make EcSOD, but the study adds that its 

production is increased by cardiovascular exercise.

“We cannot live in isolation forever,” Yan said.

 “Regular exercise has far more health 

benefits than we know. The protection 

against this severe respiratory disease 

condition is just one of the many examples.”

The director of the Center for Skeletal Muscle Research

 at UVA’s Robert M. Berne Cardiovascular Research 

Center adds that EcSOD could possibly be used 

as a treatment for ARDS. The study looks at how

 gene therapy might be used in the future to 

make more of the antioxidant in patients.

Tests on lab rats with chronic kidney 

disease have already shown that treating 

them with human EcSOD resulted in 

less kidney damage in the animals.

“We often say that exercise is medicine. 

EcSOD set a perfect example that we can 

learn from the biological process of exercise 

to advance medicine,” Yan concluded.

The study was published in the journal Redox Biology.


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